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Quantitative analysis of MGMT promoter methylation status changes by pyrosequencing in recurrent glioblastoma

11 Dec 2022

Abstract excerpt

MGMT promoter methylation status can change in response to several factors, treatment with alkylating therapy being the mechanism more commonly cited in the literature. Some authors have attempted to quantify these alterations, with inconsistent results. This study aims to determine changes in MGMT promoter methylation status by pyrosequencing, which quantitatively yields results, in a cohort of patients...

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PMID: 36504469
DOI: 10.1111/neup.12887

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