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Extent of MGMT promoter methylation modifies the effect of temozolomide on overall survival in patients with glioblastoma: a regional cohort study

1 Jan 2021

Abstract excerpt

Abstract Background MGMT methylation in glioblastoma predicts response to temozolomide but dichotomizing methylation status may mask the true prognostic value of quantitative MGMT methylation. This study evaluated whether extent of MGMT methylation interacts with the effect of temozolomide on overall survival. Methods We included consecutive glioblastoma patients aged ≥16 years diagnosed (April 2012–May 2020) at...

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PMID: 34988453
DOI: 10.1093/noajnl/vdab171

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