Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

Diabetologia - 1 Sept 2009

Reiling E, van 't Riet E, Groenewoud M J, Welschen L M C, van Hove E C, Nijpels G, Maassen J A, Dekker J M, 't Hart L M

Abstract excerpt

AIMS/HYPOTHESIS: Variation in fasting plasma glucose (FPG) within the normal range is a known risk factor for the development of type 2 diabetes. Several reports have shown that genetic variation in the genes for glucokinase (GCK), glucokinase regulatory protein (GCKR), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2) and melatonin receptor type 1B (MTNR1B) is associated with FPG. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fasting

Share to Glucokinase

Share to Glucose-6-Phosphatase

Share to Glucose Intolerance

Share to Receptor, Melatonin, MT2

Share to Reference Values

Source

Open in PubMed Open full text

Identifiers

PMID: 19533084
DOI: 10.1007/s00125-009-1413-9
PMCID: PMC2723681

Genes

GCKR
GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.PMID 19533084Read ↗

Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.Semantic proximity Read ↗

Large scale meta-analyses of fasting plasma glucose raising variants in GCK, GCKR, MTNR1B and G6PC2 and their impacts on type 2 diabetes mellitus risk.Semantic proximity Read ↗

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.Semantic proximity Read ↗

Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.Semantic proximity Read ↗

Genetic variability of GCKR alters lipid profiles in children with monogenic and autoimmune diabetes.Semantic proximity Read ↗

Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.Semantic proximity Read ↗

Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study.Semantic proximity Read ↗

Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.Semantic proximity Read ↗

Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.Semantic proximity Read ↗

Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.Semantic proximity Read ↗

Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.Semantic proximity Read ↗

Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.