Article
Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
PloS one - 8 Jul 2010
Tam Claudia Ha Ting, Ho Janice Sin Ka, Wang Ying, Lee Heung Man, Lam Vincent Kwok Lim, Germer Soren, Martin Mitchell, So Wing Yee, Ma Ronald Ching Wan, Chan Juliana Chung Ngor, Ng Maggie Chor Yin
Abstract excerpt
BACKGROUND: Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 phosphatase catalytic subunit-related protein (G6PC2), glucokinase (GCK) and glucokinase regulatory protein (GCKR) as candidate genes for type 2 diabetes (T2D) acting through elevated fasting plasma glucose (FPG). We examined the associations of the reported common variants of these genes with T2D and glucose...
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