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Article

Fragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons.

The American journal of pathology - 1 May 2005

Liazoghli Dalinda, Perreault Sebastien, Micheva Kristina D, Desjardins Mylène, Leclerc Nicole

Abstract excerpt

Tau is a microtubule-associated protein enriched in the axonal compartment. In several neurodegenerative diseases including Alzheimer's disease, hyperphosphorylated tau accumulates in the somatodendritic compartment, self-aggregates, and forms neurofibrillary tangles. A fragmentation of the neuronal Golgi apparatus (GA) was also observed in Alzheimer's disease. In the present study, we examined the effect of...

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Identifiers

PMID: 15855649
DOI: 10.1016/S0002-9440(10)62366-8
PMCID: PMC1606403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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