Article
Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005
Park Sunny, You Xiaojun, Imlay James A
Abstract excerpt
Since the discovery of catalase, it has been postulated that aerobic organisms generate enough oxidants to threaten their own fitness and, in particular, their genetic stability. An alternative is that these enzymes exist to defend the cell against more-abundant oxidants imposed by external sources. These hypotheses were tested directly through study of Hpx- (katG katE ahpCF) mutants of Escherichia coli, which...
Topics
- Catalase
- Cell Proliferation
- DNA
- DNA Damage
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Escherichia coli
- Escherichia coli Proteins
- Genetic Complementation Test
- Hydrogen Peroxide
- Hydrogen-Ion Concentration
- Hydroxyl Radical
- Iron