Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

doi:10.1016/j.imlet.2009.06.002

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Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

Immunology letters - 15 Aug 2009

Neumann Frank, Sturm Christine, Hülsmeyer Martin, Dauth Nina, Guillaume Philippe, Luescher Immanuel F, Pfreundschuh Michael, Held Gerhard

Abstract excerpt

In transplant rejection, graft versus host or autoimmune diseases T cells are mediating the pathophysiological processes. Compared to unspecific pharmacological immune suppression specific inhibition of those T cells, that are involved in the disease, would be an alternative and attractive approach. T cells are activated after their T cell receptor (TCR) recognizes an antigenic peptide displayed by the Major...

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Fab antibodies capable of blocking T cells by competitive binding have the identical specificity but a higher affinity to the MHC-peptide-complex than the T cell receptor.

Abstract excerpt

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