Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aprotinin, cardiac surgery, and factor V Leiden.

Transfusion - 1 Jan 2000

Sweeney J D, Blair A J, Dupuis M P, King T C, Moulton A L

Abstract excerpt

BACKGROUND: Aprotinin has been shown to reduce blood transfusion in cardiac surgery. Aprotinin inhibits activated protein C (APC). Patients with factor V (FV) Leiden have an inherited resistance to APC proteolysis. If the inhibition of APC by aprotinin contributes to its beneficial effect in cardiac surgery, then patients with FV Leiden undergoing cardiac surgery might be expected to require less transfusion than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor V

Share to APC gene

Share to Heterozygote

Share to Kinetics

Share to Mutation

Source

Identifiers

PMID: 9426642
DOI: 10.1046/j.1537-2995.1997.37111298088048.x

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aprotinin, cardiac surgery, and factor V Leiden.PMID 9426642Read ↗

PAI-1 gene: pharmacogenetic association of 4G/4G genotype with bleeding after cardiac surgery--pilot study.Semantic proximity Read ↗

Case report: perioperative use of protein c concentrate for protein C deficiency in THA.Semantic proximity Read ↗

Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.Semantic proximity Read ↗

Quantra Q-plus Point of Care Coagulation Analysis Reduces Blood Product Cost Burden in Patients Undergoing Cardiac SurgerySemantic proximity Read ↗

Andexanet alfa-associated heparin resistance in cardiac surgery: mechanism and <i>in vitro</i> perspectivesSemantic proximity Read ↗

Genetic factors contribute to bleeding after cardiac surgery.Semantic proximity Read ↗

Excessive bleeding and transfusion in a prior cardiac surgery is associated with excessive bleeding and transfusion in the next surgery.Semantic proximity Read ↗

Impact of activated protein C resistance on general vascular surgical patients.Semantic proximity Read ↗

Comparative effects of aprotinin and human recombinant R24K KD1 on temporal renal function in Long-Evans rats.Semantic proximity Read ↗

Severe thrombotic complications associated with activated protein C resistance acquired by orthotopic liver transplantation.Semantic proximity Read ↗

Antithrombotic and anticoagulant effects of wild type and Gla-domain mutated human activated protein C in rats.Semantic proximity Read ↗

Complement activation by heparin-protamine complexes during cardiopulmonary bypass: effect of C4A null allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.