Article
Association study between the LINGO1 gene and Parkinson's disease in the Italian population.
Parkinsonism & related disorders - 1 Sept 2011
Annesi F, De Marco E V, Rocca F E, Nicoletti A, Pugliese P, Nicoletti G, Arabia G, Tarantino P, De Mari M, Lamberti P, Gallerini S, Marconi R, Epifanio A, Morgante L, Cozzolino A, Barone P, Torchia G, Zappia M, Annesi G, Quattrone A
Abstract excerpt
Some studies have suggested an overlap of clinical and genetic findings between essential tremor (ET) and Parkinson's disease (PD). The first genome-wide association study in ET showed a significant association with the rs9652490 SNP of the leucine-rich repeat and Ig domain containing 1 (LINGO1) gene. Since patients with PD have higher LINGO1 expression levels compared to healthy controls, and animal models of PD...
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