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Article

Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study.

Journal of experimental & clinical cancer research : CR - 28 Jul 2008

Fan Hong, Zhang Feng, Hu Jiabo, Liu Dongsheng, Zhao Zhujiang

Abstract excerpt

BACKGROUND: DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer. METHODS: DNMT3B -579G>T genotypes and -149C>T were determined by PCR-RFLP and sequencing in 137 colorectal cancer...

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Source

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Identifiers

PMID: 18662374
DOI: 10.1186/1756-9966-27-24
PMCID: PMC2515831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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