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Article

Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer.

International journal of colorectal disease - 1 Sept 2011

Bao Qian, He Bangshun, Pan Yuqin, Tang Zhipeng, Zhang Ying, Qu Lili, Xu Yongfei, Zhu Chan, Tian Fuliang, Wang Shukui

Abstract excerpt

PURPOSE: DNA methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B enzyme activity on DNA methylation, thereby modulating the susceptibility to colorectal cancer (CRC). METHODS: The polymorphisms in the promoter region of the DNMT3B gene [-149C>T (rs2424913) and -579G>T (rs1569686)] were detected by...

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PMID: 21519807
DOI: 10.1007/s00384-011-1199-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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