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Article

Placenta-derived fetal specific mRNA is more readily detectable in maternal plasma than in whole blood.

PloS one - 10 Jun 2009

Heung Macy M S, Jin Shengnan, Tsui Nancy B Y, Ding Chunming, Leung Tak Y, Lau Tze K, Chiu Rossa W K, Lo Y M Dennis

Abstract excerpt

BACKGROUND: Placental mRNA was detected in maternal whole blood, raising the possibility of using maternal blood for noninvasive prenatal diagnosis. We investigated fetal mRNA detection in maternal whole blood and determined if it offered advantages over maternal plasma analysis. METHODOLOGY: The concentrations of placental expressed genes, CSH1, KISS1, PLAC4 and PLAC1 in plasma and whole blood from healthy...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19516908
DOI: 10.1371/journal.pone.0005858
PMCID: PMC2690655

Genes

KISS1
PLAC1
CEACAM8
CSH1
DEFA4
MMP8
MPO
OLFM4
ORM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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