Article
Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood.
The Journal of clinical investigation - 1 Oct 2007
Maron Jill L, Johnson Kirby L, Slonim Donna, Lai Chao-Qiang, Ramoni Marco, Alterovitz Gil, Jarrah Zina, Yang Zinger, Bianchi Diana W
Abstract excerpt
The discovery of fetal mRNA transcripts in the maternal circulation holds great promise for noninvasive prenatal diagnosis. To identify potential fetal biomarkers, we studied whole blood and plasma gene transcripts that were common to 9 term pregnant women and their newborns but absent or reduced in the mothers postpartum. RNA was isolated from peripheral or umbilical blood and hybridized to gene expression...
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