Article
Detection of the placental epigenetic signature of the maspin gene in maternal plasma.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2005
Chim Stephen S C, Tong Yu K, Chiu Rossa W K, Lau Tze K, Leung Tse N, Chan Lisa Y S, Oudejans Cees B M, Ding Chunming, Lo Y M Dennis
Abstract excerpt
The discovery of fetal DNA in the plasma of pregnant women has opened up new approaches for noninvasive prenatal diagnosis and monitoring. Up to now, the lack of a fetal DNA marker that can be universally detected in maternal plasma has limited the clinical application of this technology. We hypothesized that epigenetic differences between the placenta and maternal blood cells could be used for developing such a...
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