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Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.

Blood - 13 Aug 2009

Ansari Marc, Sauty Géraldine, Labuda Malgorzata, Gagné Vincent, Laverdière Caroline, Moghrabi Albert, Sinnett Daniel, Krajinovic Maja

Abstract excerpt

Methotrexate and 6-mercaptopurine, important components of acute lymphoblastic leukemia treatment, are substrates for multidrug resistance-associated protein MRP4. Eight single nucleotide polymorphisms were analyzed in MRP4 gene, and 4 variants were identified as tagSNPs with frequency more than or equal to 5%. They were investigated for association with treatment responses in 275 children with acute...

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Identifiers

PMID: 19515727
DOI: 10.1182/blood-2008-11-191098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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