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Article

IDH1 Mutation Induces HIF-1α and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells.

Disease markers - 1 Jan 2022

Hu Xiaoyu, Li Luyuan, Eid Josiane E, Liu Chao, Yu Jinming, Yue Jinbo, Trent Jonathan C

Abstract excerpt

Chondrosarcoma is a group of primary bone cancers that arise from transformed cells of chondrocytic lineage. Tumor recurrence and metastasis are devastating for patients with chondrosarcoma since there are no effective treatment options. IDH mutations occur in over 50% of tumors from patients with conventional or dedifferentiated chondrosarcomas and represent an attractive target for therapy. However, their role...

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Share to Bone Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Isocitrate Dehydrogenase

Share to Neovascularization, Pathologic

Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 35198082
DOI: 10.1155/2022/7729968
PMCID: PMC8860547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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