A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

Abstract excerpt

Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality. Here, we aim to uncover the transcriptional program directing such tumor progression in chondrosarcomas. We conduct weighted correlation network analysis to extract a characteristic gene module underlying chondrosarcoma...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Tumor Diagnosis and Treatments
• Share to Cancer-related molecular mechanisms research
• Share to Sarcoma Diagnosis and Treatment