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Article

Immortalization without neoplastic transformation of human mesenchymal stem cells by transduction with HPV16 E6/E7 genes.

International journal of cancer - 20 Jun 2004

Hung Shih-Chieh, Yang Den-Mei, Chang Ching-Fang, Lin Ruey-Jen, Wang Jih-Shiuan, Low-Tone Ho Larry, Yang Wen K

Abstract excerpt

hMSCs derived from bone marrow are useful as a species-specific cell culture system for studying cell lineage differentiation and tissue remodeling. However, hMSCs usually have a short in vitro life span due to replicative senescence. We therefore used a high dose of retroviral vector LXSN-16E6E7 to transduce hMSCs of an aging donor and obtained an actively proliferating cell line, designated KP-hMSCs, which...

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PMID: 15095294
DOI: 10.1002/ijc.20126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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