Article
Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells.
PLoS pathogens - 1 Jun 2009
Vasilakis Nikos, Deardorff Eleanor R, Kenney Joan L, Rossi Shannan L, Hanley Kathryn A, Weaver Scott C
Abstract excerpt
Like other arthropod-borne viruses (arboviruses), mosquito-borne dengue virus (DENV) is maintained in an alternating cycle of replication in arthropod and vertebrate hosts. The trade-off hypothesis suggests that this alternation constrains DENV evolution because a fitness increase in one host usually diminishes fitness in the other. Moreover, the hypothesis predicts that releasing DENV from host alternation...
Topics
- Adaptation, Biological
- Aedes
- Analysis of Variance
- Animals
- Arboviruses
- Cell Line
- Cell Line, Tumor
- Chlorocebus aethiops
- Consensus Sequence
- Dengue Virus
- Evolution, Molecular
- Humans
- Kinetics
- Mutation