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Article

Mosquitoes put the brake on arbovirus evolution: experimental evolution reveals slower mutation accumulation in mosquito than vertebrate cells.

PLoS pathogens - 1 Jun 2009

Vasilakis Nikos, Deardorff Eleanor R, Kenney Joan L, Rossi Shannan L, Hanley Kathryn A, Weaver Scott C

Abstract excerpt

Like other arthropod-borne viruses (arboviruses), mosquito-borne dengue virus (DENV) is maintained in an alternating cycle of replication in arthropod and vertebrate hosts. The trade-off hypothesis suggests that this alternation constrains DENV evolution because a fitness increase in one host usually diminishes fitness in the other. Moreover, the hypothesis predicts that releasing DENV from host alternation...

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Identifiers

PMID: 19503824
DOI: 10.1371/journal.ppat.1000467
PMCID: PMC2685980

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