Article
Chikungunya virus produced by a persistently infected mosquito cell line comprises a shorter genome and is non-infectious to mammalian cells.
The Journal of general virology - 1 Dec 2021
de Oliveira Athos S, Vasconcellos Anna Fernanda, Rodrigues Bruno M P, da Silva Leonardo A, Resende Renato O, Ribeiro Bergmann M
Abstract excerpt
Although RNA viruses have high mutation rates, host cells and organisms work as selective environments, maintaining the viability of virus populations by eliminating deleterious genotypes. In serial passages of RNA viruses in a single cell line, most of these selective bottlenecks are absent, with no virus circulation and replication in different tissues or host alternation. In this work, Aedes aegypti Aag-2...
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