Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840.

Molecular pharmacology - 1 Apr 2014

Jenkins Meagan A, Wells Gordon, Bachman Julia, Snyder James P, Jenkins Andrew, Huganir Richard L, Oswald Robert E, Traynelis Stephen F

Abstract excerpt

Three residues within the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor subunit GluA1 C terminus (Ser818, Ser831, Thr840) can be phosphorylated by Ca(2+)/phospholipid-dependent protein kinase (PKC). Here, we show that PKC phosphorylation of GluA1 Ser818 or Thr840 enhances the weighted mean channel conductance without altering the response time course or agonist potency. These data support...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells
Share to Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Patch-Clamp Techniques

Share to Primary Cell Culture

Share to Protein Kinase C

Share to Receptors, AMPA

Share to Serine

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 24452473
DOI: 10.1124/mol.113.091488
PMCID: PMC4014661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840.PMID 24452473Read ↗

Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation.Semantic proximity Read ↗

PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression.Semantic proximity Read ↗

Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptors.Semantic proximity Read ↗

Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.Semantic proximity Read ↗

Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.Semantic proximity Read ↗

Diversity in AMPA receptor complexes in the brain.Semantic proximity Read ↗

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation.Semantic proximity Read ↗

Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus.Semantic proximity Read ↗

Functional insight into development of positive allosteric modulators of AMPA receptors.Semantic proximity Read ↗

A desensitization-inhibiting mutation in the glutamate binding site of rat alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is dominant in heteromultimeric complexes.Semantic proximity Read ↗

Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor.Semantic proximity Read ↗

Phosphorylation of glutamate receptor interacting protein 1 regulates surface expression of glutamate receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.