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Article

Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease.

Annals of hepatology - 1 Jan 2000

Oruc Nevin, Ozutemiz Omer, Berdeli Afig, Ersoz Galip, Gunsar Fulya, Karasu Zeki, Ilter Tankut, Batur Yucel, Akarca Ulus Salih

Abstract excerpt

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is common in obese and diabetics. Serine protease inhibitor Kazal-1 (SPINK-1) protein is highly expressed in the liver and adipose tissue of diabetic and obese suggesting its role in NAFLD. SPINK-1 also behaves as an acute phase reactant protein. Some genetic factors including the genetic variations in SPINK-1 protein have been linked to chronic pancreatitis...

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PMID: 19502653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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