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Article

N34S mutation in the SPINK1 gene is not associated with alternative splicing.

Pancreas - 1 May 2007

Masamune Atsushi, Kume Kiyoshi, Takagi Yasuhiko, Kikuta Kazuhiro, Satoh Kennichi, Satoh Akihiko, Shimosegawa Tooru

Abstract excerpt

OBJECTIVES: Previous studies have shown an association between chronic pancreatitis (CP) and mutations, especially the N34S mutation, in the serine protease inhibitor Kazal type 1 (SPINK1) gene. But the underlying molecular mechanisms are unknown. The aberrant splicing caused by the cosegregating intronic mutations might play a role, but this hypothesis has not been tested. We here examined the messenger RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17446841
DOI: 10.1097/mpa.0b013e3180335fd0

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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