Article
An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.
Molecular and cellular biology - 1 Feb 1999
Vollenweider P, Clodi M, Martin S S, Imamura T, Kavanaugh W M, Olefsky J M
Abstract excerpt
Tyrosine kinase receptors lead to rapid activation of phosphatidylinositol 3-kinase (PI3 kinase) and the subsequent formation of phosphatidylinositides (PtdIns) 3,4-P2 and PtdIns 3,4, 5-P3, which are thought to be involved in signaling for glucose transporter GLUT4 translocation, cytoskeletal rea...
Topics
- 3T3 Cells
- Actins
- Amino Acid Sequence
- Animals
- Biological Transport, Active
- Bromodeoxyuridine
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cell Membrane
- DNA
- Enzyme Activation
- Glucose Transporter Type 4
- Guanosine 5'-O-(3-Thiotriphosphate)
- Humans