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Article

A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.

Journal of molecular biology - 31 Jul 2009

Gwyn Lori M, Peak Mandy M, De Pallabi, Rahman Negar S, Rodgers Karla K

Abstract excerpt

The recombination-activating protein, RAG1, a key component of the V(D)J recombinase, binds multiple Zn(2+) ions in its catalytically required core region. However, the role of zinc in the DNA cleavage activity of RAG1 is not well resolved. To address this issue, we determined the stoichiometry of Zn(2+) ions bound to the catalytically active core region of RAG1 under various conditions. Using metal quantitation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19500590
DOI: 10.1016/j.jmb.2009.05.076
PMCID: PMC2782368

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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