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Article

The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status.

International journal of oncology - 1 Sept 2011

Stenger Christophe, Naves Thomas, Verdier Mireille, Ratinaud Marie-Helene

Abstract excerpt

Cobalt chloride (CoCl2), a hypoxia-mimetic agent, induces reactive oxygen species (ROS) generation, leading to cell death. Divergent data have been reported concerning p53 implication in this apoptotic mechanism. In this study, we studied cobalt-induced cell death in neuroblastoma cell lines carrying wild-type (WT) p53 ( SHSY5Y) and a mutated DNA-binding domain p53 [SKNBE(2c)]. CoCl2 induced an upregulation of...

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Identifiers

PMID: 21687937
DOI: 10.3892/ijo.2011.1083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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