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Article

The cytotoxicity of chemotherapy drugs varies in cervical cancer cells depending on the p53 status.

Cancer biology & therapy - 1 Nov 2004

Koivusalo Riku, Hietanen Sakari

Abstract excerpt

Metastatic cervical cancer remains a clinical problem. The development of more efficient treatment modalities and the optimal use of chemo- and radiotherapy require better understanding of their impact on regulation of cell survival and apoptosis, but the issue is insufficiently explored. Human papillomavirus (HPV) E6 protein is present in nearly all cervical cancers, targeting the p53 tumor suppressor protein...

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Source

Identifiers

PMID: 15640620
DOI: 10.4161/cbt.3.11.1340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The cytotoxicity of chemotherapy drugs varies in cervical cancer cells depending on the p53 status.PMID 15640620Read ↗

Anticancer Drugs Aimed at E6 and E7 Activity in HPV-Positive Cervical CancerSemantic proximity Read ↗

[Effect of HPV16E6 on sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines].Semantic proximity Read ↗

Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer CellsSemantic proximity Read ↗

Specific HIV Protease Inhibitors Inhibit the Ability of Hpv16 E6 to Degrade P53 and Selectively Kill E6-Dependent Cervical Carcinoma Cells In VitroSemantic proximity Read ↗

Suppression of E6 Oncogene Induces Apoptosis in CaSki Cervical Cancer CellsSemantic proximity Read ↗

Involvement of p53-dependent apoptosis signal in antitumor effect of Colchicine on human papilloma virus (HPV)-positive human cervical cancer cellsSemantic proximity Read ↗

Meta-analysis of the role of p53 status in isogenic systems tested for sensitivity to cytotoxic antineoplastic drugs.Semantic proximity Read ↗

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Activation of p53 in cervical carcinoma cells by small moleculesSemantic proximity Read ↗

Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cellsSemantic proximity Read ↗

Small molecule nonsense mediated mRNA decay and MDM2-p53 inhibitors synergistically induce apoptosis in cervical cancer cellsSemantic proximity Read ↗

Human papillomavirus 16 E6 increases the radiosensitivity of p53-mutated cervical cancer cells, associated with up-regulation of aurora A.Semantic proximity Read ↗

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