Article
Conjugated linoleic acids (CLAs) regulate the expression of key apoptotic genes in human breast cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2002
Majumder Barun, Wahle Klaus W J, Moir Susanne, Schofield Andrew, Choe Sun-Nam, Farquharson Andrew, Grant Ian, Heys Steven D
Abstract excerpt
Conjugated linoleic acid (CLA) reduces mammary tumorigenesis in rodent models, induces apoptosis in rodent mammary tumor cell lines, and decreases expression of antiapoptotic bcl-2 in rat mammary tissue. This investigation focused on the cell mechanisms underlying the antitumor effects of CLA. Changes (mRNA, protein) in expression of major proapoptotic p53, p21WAF1/CIP1, bax, bcl-Xs genes, and the antiapoptotic...
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