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Article

Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jul 2024

Karliner Jordyn, Liu Yuhong, Merry Diane E

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease caused by a polyglutamine (polyQ)-encoding CAG trinucleotide repeat expansion in the androgen receptor (AR) gene, leading to AR aggregation, lower motor neuron death, and muscle atrophy. AR is a ligand-activated transcription factor that regulates neuronal architecture and promotes axon regeneration; however, whether AR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38976730
DOI: 10.1073/pnas.2321408121
PMCID: PMC11260106

Genes

AR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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