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Article

The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder rats.

Pharmacology, biochemistry, and behavior - 1 Sept 2008

Davis Brooke A, Clinton Sarah M, Akil Huda, Becker Jill B

Abstract excerpt

Individual differences in exploratory behavior can predictably influence psychostimulant self-administration behavior. Male rats that exhibit a high degree of locomotor activity in a novel environment (High Responders, HR) will self-administer cocaine more readily than males exhibiting low levels of novelty-induced locomotion (Low Responders, LR). The present experiment investigates the combined influences of the...

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Identifiers

PMID: 18445506
DOI: 10.1016/j.pbb.2008.03.008
PMCID: PMC2474787

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