High novelty-seeking rats are resilient to negative physiological effects of the early life stress.

doi:10.3109/10253890.2013.850670

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Article

High novelty-seeking rats are resilient to negative physiological effects of the early life stress.

Stress (Amsterdam, Netherlands) - 1 Jan 2014

Clinton Sarah M, Watson Stanley J, Akil Huda

Abstract excerpt

Exposure to early life stress dramatically impacts adult behavior, physiology, and neuroendocrine function. Using rats bred for novelty-seeking differences and known to display divergent anxiety, depression, and stress vulnerability, we examined the interaction between early life adversity and genetic predisposition for high- versus low-emotional reactivity. Thus, bred Low Novelty Responder (bLR) rats, which...

Topics

Adrenocorticotropic Hormone
Animals
Animals, Newborn
Anxiety
Behavior, Animal
Corticosterone
Depression
Eliminative Behavior, Animal
Exploratory Behavior
Female
Genetic Predisposition to Disease
Male
Maternal Deprivation
Motor Activity
Rats
Stress, Psychological

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Identifiers

PMID: 24090131
DOI: 10.3109/10253890.2013.850670
PMCID: PMC4141530

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