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Article

A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Spach Karen M, Noubade Rajkumar, McElvany Ben, Hickey William F, Blankenhorn Elizabeth P, Teuscher Cory

Abstract excerpt

Genes controlling immunopathologic diseases of differing etiopathology may also influence susceptibility to autoimmune disease. B10.D1-H2(q)/SgJ mice with a 2538 G-->A missense mutation in the tyrosine kinase-2 gene (Tyk2) are susceptible to Toxoplasma gondii yet resistant to autoimmune arthritis, unlike the wild-type B10.Q/Ai substrain. To understand whether Tyk2 is also important in a second autoimmune model,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Source

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Identifiers

PMID: 19494301
DOI: 10.4049/jimmunol.0900142
PMCID: PMC3008628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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