Article
Human papillomavirus genotype specificity of hybrid capture 2 low-risk probe cocktail.
Journal of clinical microbiology - 1 Aug 2009
Poljak Mario, Kocjan Bostjan J, Kovanda Anja, Lunar Maja M, Lepej Snjezana Zidovec, Planinic Ana, Seme Katja, Vince Adriana
Abstract excerpt
A genotyping study of 285 Hybrid Capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. Cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. A total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. Establishment of a gray zone is recommended.
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