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Article

How Do Human Cells React to the Absence of Mitochondrial DNA?

27 May 2009

Abstract excerpt

BACKGROUND: Mitochondrial biogenesis is under the control of two different genetic systems: the nuclear genome (nDNA) and the mitochondrial genome (mtDNA). The mtDNA is a circular genome of 16.6 kb encoding 13 of the approximately 90 subunits that form the respiratory chain, the remaining ones being encoded by the nDNA. Eukaryotic cells are able to monitor and respond to changes in mitochondrial function through...

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PMID: 19492094
DOI: 10.1371/journal.pone.0005713

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