Article
Differences in nuclear gene expression between cells containing monomer and dimer mitochondrial genomes.
Gene - 6 Mar 2002
Clark Kim M, Brown Timothy A, Davidson Mercy M, Papadopoulou Lefkothea C, Clayton David A
Abstract excerpt
It is known that point mutations and rearrangements (deletions and duplications) of mammalian mitochondrial DNA (mtDNA) can result in mitochondrial dysfunction and human disease. Very little attention has been paid to mtDNA circular dimers (a complex form consisting of two genomes joined head-to-tail) despite their close association with human neoplasia. MtDNA dimers are frequently found in human leukemia, but...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.