Article
Capped acyclic permutants of the circular protein kalata B1.
FEBS letters - 19 Nov 2004
Simonsen Shane M, Daly Norelle L, Craik David J
Abstract excerpt
The cyclotides are a family of head-to-tail cyclized peptides that display exceptionally high stability and a range of biological activities. Acyclic permutants that contain a break in the circular backbone have been reported to be devoid of the haemolytic activity of the prototypic cyclotide kalata B1, but the potential role of the charges at the introduced termini in this loss of membraneolytic activity has not...
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