Article
Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.
The Journal of biological chemistry - 17 Jul 2009
Xu Deming, Sillaots Susan, Davison John, Hu Wenqi, Jiang Bo, Kauffman Sarah, Martel Nick, Ocampo Pam, Oh Chanseok, Trosok Steve, Veillette Karynn, Wang Hao, Yang Minghui, Zhang Li, Becker Jeffrey, Martin Charles E, Roemer Terry
Abstract excerpt
The balance between saturated and unsaturated fatty acids plays a crucial role in determining the membrane fluidity. In the diploid fungal pathogen Candida albicans, the gene for fatty acid Delta9 desaturase, OLE1, is essential for viability. Using a reverse genetic approach, termed the fitness test, we identified a group of structurally related synthetic compounds that induce specific hypersensitivity of the...
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