Article
Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus.
Infection and immunity - 1 Jul 2008
Dagenais Taylor R T, Chung Dawoon, Giles Steven S, Hull Christina M, Andes David, Keller Nancy P
Abstract excerpt
Oxygenated fatty acids, or oxylipins, play an essential role in physiological signaling and developmental processes in animals, plants, and fungi. Previous characterization of three Aspergillus fumigatus dioxygenases (PpoA, PpoB, and PpoC), similar in sequence to mammalian cyclooxygenases, showed that PpoA is responsible for the production of the oxylipins 8R-hydroperoxyoctadecadienoic acid and...
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