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Article

Variants in KITLG predispose to testicular germ cell cancer independently from spermatogenic function.

Endocrine-related cancer - 1 Feb 2012

Ferlin Alberto, Pengo Manuel, Pizzol Damiano, Carraro Umberto, Frigo Anna Chiara, Foresta Carlo

Abstract excerpt

Epidemiological data suggest an association and a common pathogenetic link between male infertility and testicular germ cell tumor (TGCT) development. Genome-wide studies identified that TGCT susceptibility is associated with KITLG (c-KIT ligand), which regulates the formation of primordial germ cells, from which TGCT is believed to arise and spermatogenesis develops. In this study, we analyzed the link between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22194441
DOI: 10.1530/ERC-11-0340

Genes

KITLG
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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