Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human RIF1 encodes an anti-apoptotic factor required for DNA repair

29 May 2009

Abstract excerpt

Human Rap1-interacting protein 1 (RIF1) contributes to the ataxia telangiectasia, mutated-mediated DNA damage response against the dexterous effect of DNA lesions and plays a critical role in the S-phase checkpoint. However, the molecular mechanisms by which human RIF1 conquers DNA aberrations remain largely unknown. We here showed that inhibition of RIF1 expression by small interfering RNA led to defective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19483192
DOI: 10.1093/carcin/bgp136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human RIF1 encodes an anti-apoptotic factor required for DNA repairPMID 19483192Read ↗

RIF1: A novel regulatory factor for DNA replication and DNA damage response signalingSemantic proximity Read ↗

The role of BRCA1 in DNA damage response.Semantic proximity Read ↗

RB1 dual role in proliferation and apoptosis: Cell fate control and implications for cancer therapySemantic proximity Read ↗

The role of BRCA1 in DNA double-strand repair: past and present.Semantic proximity Read ↗

RAP1/TERF2IP—A Multifunctional Player in Cancer DevelopmentSemantic proximity Read ↗

Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cellsSemantic proximity Read ↗

Rap2b, a novel p53 target, regulates p53-mediated pro-survival functionSemantic proximity Read ↗

DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancerSemantic proximity Read ↗

MCL-1 plays an oncogenic role in breast cancer by modulating chemoresistance and stemness properties by activating Wnt/β-cateninSemantic proximity Read ↗

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cellsSemantic proximity Read ↗

ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistanceSemantic proximity Read ↗

Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.