Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition.

Cancer genetics and cytogenetics - 1 Jul 2009

Bug Stefanie, Dürig Jan, Oyen Florian, Klein-Hitpass Ludger, Martin-Subero Jose I, Harder Lana, Baudis Michael, Arnold Norbert, Kordes Uwe, Dührsen Ulrich, Schneppenheim Reinhard, Siebert Reiner

Abstract excerpt

In T-cell prolymphocytic leukemia (T-PLL), chromosomal imbalances affecting the long arm of chromosome 22 are regarded as typical chromosomal aberrations secondary to a TCRAD-TCL1A fusion due to inv(14) or t(14;14). We analyzed recently obtained data from conventional karyotyping, SNP-chip array copy number mapping, genome-wide expression profiling, and interphase fluorescence in situ hybridization (FISH) of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to Gene Deletion

Share to Genes, Tumor Suppressor

Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins

Share to SMARCB1 Protein

Source

Identifiers

PMID: 19480937
DOI: 10.1016/j.cancergencyto.2009.03.001

Genes

SMARCB1
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition.PMID 19480937Read ↗

Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32).Semantic proximity Read ↗

Reconstruction of rearranged T-cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T-cell prolymphocytic leukemia.Semantic proximity Read ↗

SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.Semantic proximity Read ↗

Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.Semantic proximity Read ↗

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.Semantic proximity Read ↗

High levels of chromosomal imbalances in typical and small-cell variants of T-cell prolymphocytic leukemia.Semantic proximity Read ↗

Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma.Semantic proximity Read ↗

High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays.Semantic proximity Read ↗

Prognostic significance of cytogenetic abnormalities in T‐cell prolymphocytic leukemiaSemantic proximity Read ↗

Deletion of chromosomal region 13q14.3 in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Gain of a region on 7p22.3, containing <i>MAD1L1</i>, is the most frequent event in small‐cell lung cancer cell linesSemantic proximity Read ↗

tSNP-based identification of allelic loss of gene expression in a patient with a balanced chromosomal rearrangement.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.