Article
Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jun 2009
Karaźniewicz-Łada M, Luczak M, Główka F
Abstract excerpt
The pharmacokinetics of ibuprofen enantiomers and its chiral metabolites, namely (R,S)-29-hydroxyibuprofen and (RR,RS,SR,SS)-29-carboxyibuprofen, was studied in healthy volunteers carrying different alleles coding cytochrome P450 (CYP) 4502C isoenzymes. Following administration of 400 mg of racemic ibuprofen, enantiomers of the parent compound and their metabolites were isolated from plasma and urine samples...
Topics
- Adolescent
- Adult
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP2C9
- Electrophoresis, Capillary
- Female
- Genetic Variation
- Genotype
- Humans
- Ibuprofen
- Isoenzymes
- Male