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Article

The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

British journal of clinical pharmacology - 1 Jan 2005

Martínez Carmen, García-Martín Elena, Blanco Gerardo, Gamito Francisco J G, Ladero José M, Agúndez José A G

Abstract excerpt

AIMS: To study the effect of CYP2C8*3, the most common CYP2C8 variant allele on the dis-position of (R)-ibuprofen and the association of CYP2C8*3 with variant CYP2C9 alleles. METHODS: Three hundred and fifty-five randomly selected Spanish Caucasians were screened for the common CYP2C8 and CYP2C9 mutations. The pharmacokinetics of (R)-ibuprofen were studied in 25 individuals grouped into different CYP2C8...

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Identifiers

PMID: 15606441
DOI: 10.1111/j.1365-2125.2004.02183.x
PMCID: PMC1884959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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