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Article

Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen.

European journal of clinical pharmacology - 1 May 2007

Tornio Aleksi, Niemi Mikko, Neuvonen Pertti J, Backman Janne T

Abstract excerpt

OBJECTIVE: Ibuprofen, a nonsteroidal anti-inflammatory agent, is metabolised in vitro by cytochrome P450 (CYP) 2C8 and 2C9. We studied the possible effect of gemfibrozil, an in vivo inhibitor of CYP2C8, on the pharmacokinetics of ibuprofen in healthy volunteers. METHODS: In a randomised two-phase crossover study, 10 healthy volunteers took 600 mg gemfibrozil or placebo orally twice daily for 3 days. On day 3,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17333159
DOI: 10.1007/s00228-007-0273-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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