Article
Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.
Infection and immunity - 1 Dec 2012
Béla Samantha R, Dutra Míriam S, Mui Ernest, Montpetit Alexandre, Oliveira Fernanda S, Oliveira Sérgio C, Arantes Rosa M E, Antonelli Lis R, McLeod Rima, Gazzinelli Ricardo T
Abstract excerpt
Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing the production of inflammatory mediators. This kinase is downstream of MyD88, an adaptor protein essential for Toll-like receptor (TLR) function. We investigated the role of this kinase in IRAK4-deficient mice orally infected with the cystogenic ME49 strain of Toxoplasma gondii....
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