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Article

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

Nature - 18 Mar 1993

Kopf M, Le Gros G, Bachmann M, Lamers M C, Bluethmann H, Köhler G

Abstract excerpt

Murine T-helper clones are classified into two distinct subsets (Th1 and Th2) on the basis of their patterns of lymphokine secretion. Th1 clones secrete interleukin-2 (IL-2), tumour necrosis factor-beta (TNF-beta) and interferon-gamma (IFN-gamma), whereas Th2 clones secrete IL-4, IL-5 and IL-10 (ref. 1). These subsets are reciprocally regulated by IL-4, IL-10 and IFN-gamma and differentially promote antibody or...

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PMID: 8384701
DOI: 10.1038/362245a0

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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