High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

doi:10.1371/journal.pone.0005231

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Article

High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

PloS one - 29 May 2009

Kashuba Vladimir I, Pavlova Tatiana V, Grigorieva Elvira V, Kutsenko Alexey, Yenamandra Surya Pavan, Li Jingfeng, Wang Fuli, Protopopov Alexei I, Zabarovska Veronika I, Senchenko Vera, Haraldson Klas, Eshchenko Tatiana, Kobliakova Julia, Vorontsova Olga, Kuzmin Igor, Braga Eleonora, Blinov Vladimir M, Kisselev Lev L, Zeng Yi-Xin, Ernberg Ingemar, Lerman Michael I, Klein George, Zabarovsky Eugene R

Abstract excerpt

BACKGROUND: Many different genetic alterations are observed in cancer cells. Individual cancer genes display point mutations such as base changes, insertions and deletions that initiate and promote cancer growth and spread. Somatic hypermutation is a powerful mechanism for generation of different mutations. It was shown previously that somatic hypermutability of proto-oncogenes can induce development of...

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Identifiers

PMID: 19478941
DOI: 10.1371/journal.pone.0005231
PMCID: PMC2684631

Genes

RASSF1
CTDSPL

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