Article
Oncogenic signaling pathways and deregulated target genes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 2007
Schäfer Reinhold, Schramme Anja, Tchernitsa Oleg I, Sers Christine
Abstract excerpt
A limited number of somatic mutations are known to trigger malignancy via chronic activation of cellular signaling pathways. High-throughput analysis of gene expression in cancer cells has revealed a plethora of deregulated genes by far exceeding the number of known genetic alterations. Targeted tumor therapy takes advantage of deregulated signaling in cancer. However, cancer cells may evade successful therapy,...
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