Article
JNK3 couples the neuronal stress response to inhibition of secretory trafficking.
Science signaling - 9 Jul 2013
Yang Guang, Zhou Xun, Zhu Jingyan, Liu Rui, Zhang Si, Coquinco Ainsley, Chen Yongting, Wen Yanhua, Kojic Luba, Jia William, Cynader Max S
Abstract excerpt
Secretory trafficking through the Golgi complex is critical for neuronal development, function, and stress response. Altered secretion is associated with the pathogenesis of various neurological diseases. We found that c-Jun amino-terminal kinase 3 (JNK3) inhibited secretory trafficking by promoting the depletion of phosphatidylinositol 4-phosphate (PI4P) in the Golgi complex of COS7 cells and primary rat...
Topics
- Acyltransferases
- Animals
- Biological Transport, Active
- COS Cells
- Chlorocebus aethiops
- Excitatory Amino Acid Agonists
- Golgi Apparatus
- Inositol Polyphosphate 5-Phosphatases
- Lipoylation
- Mitogen-Activated Protein Kinase 10