Article
An association between Epac-1 gene variants and anxiety and depression in two independent samples.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Middeldorp Christel M, Vink Jacqueline M, Hettema John M, de Geus Eco J C, Kendler Kenneth S, Willemsen Gonneke, Neale Michael C, Boomsma Dorret I, Chen Xiangning
Abstract excerpt
Deficiency in signal transduction might play a role in the development of anxiety and depression, as suggested by a study on the involvement of the PKA-independent Epac pathway. We investigated the association between Epac-1 gene variants, also known as RapGEF-3, and measures of anxiety and depression in a Dutch twin-family sample. Replication was sought in a USA sample consisting of unrelated individuals....
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